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What defines a substance as a drug?

  1. Its ability to enhance physical performance

  2. Its use in the diagnosis, treatment, mitigation, or prevention of diseases in humans or animals

  3. Its addictive properties

  4. Its natural origin, such as plants or minerals

The correct answer is: Its use in the diagnosis, treatment, mitigation, or prevention of diseases in humans or animals

A substance is considered a drug based on its purpose and intended use. Option A may be a potential effect of some drugs, but it is not the defining factor. Option C may be a common characteristic of some drugs, but it does not encompass all substances that are considered drugs. Option D is also not a defining factor, as not all drugs have natural origins. Option B is the correct answer because it encompasses the main purpose of drugs, which is to treat or prevent diseases in humans or animals.