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What dictates the frequency of methadone dose adjustments during the maintenance phase?

  1. Pharmacist's discretion

  2. Patient request

  3. Typically between 5 and 10 mg adjustments

  4. Dose never changes once set

The correct answer is: Typically between 5 and 10 mg adjustments

During the maintenance phase of methadone treatment, the frequency of dose adjustments is typically between 5 and 10 mg. This means that the dose may be adjusted up or down by these increments in order to achieve the proper balance and effectiveness of the medication for each individual patient. Option A, the pharmacist's discretion, may play a role in determining the exact dosage, but it is not the primary factor influencing frequency of adjustments. Option B, patient request, is not a reliable factor in determining dose adjustments as it may not be in the best interest of the patient's treatment plan. Option D, that the dose never changes once set, is incorrect as the dose may need to be adjusted throughout the maintenance phase.